An amphiphilic Ru-containing block copolymer self-assembles into nanoparticles. These nanoparticles accumulate at the tumor sit. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic 1O2, both of which can inhibit tumor growth.
An amphiphilic Ru-containing polymetallodrug was used for anticancer phototherapy
By coupling the cytokine interleukin-2 to the surface of hydroxyethylstarch nanocapsules, a direct and specific T cell targeting in vitro and in vivo by receptor mediated internalization can be achieved.
Targeting of T cells for biomedical applications still remains an obstacle as they disclose reduced endocytic activities. Here, by coupling the cytokine interleukin-2 (IL-2) to the surface of hydroxyethyl starch nanocapsules, scientists of the MPI-P and the University Medical Center Mainz demonstrated a direct and specific T cell targeting in vitro and in vivo by IL-2 receptor mediated internalization.
By coupling the cytokine interleukin-2 to the surface of hydroxyethylstarch nanocapsules, a direct and specific T cell targeting in vitro and in vivo by receptor mediated internalization can be achieved.