Highlight Publications 2017

An amphiphilic ruthenium polymetallodrug for combined photodynamic therapy and photochemotherapy in vivo
Wen Sun, Shuyi Li, Bernhard Häupler, Juan Liu, Shubin Jin, Werner Steffen, Ulrich S. Schubert, Hans-Jürgen Butt, Xing-Jie Liang, Si Wu
An amphiphilic ruthenium polymetallodrug for combined photodynamic therapy and photochemotherapy in vivo
An amphiphilic Ru-containing block copolymer self-assembles into nanoparticles. These nanoparticles accumulate at the tumor sit. Red light irradiation of the block copolymer nanoparticles releases anticancer Ru complexes and generates cytotoxic 1O2, both of which can inhibit tumor growth.
© Wiley (2017)
An amphiphilic Ru-containing polymetallodrug was used for anticancer phototherapy
IL-2 functionalized nanocapsules for T cell-based immunotherapy
S.U. Frick, M.P. Domogalla, G. Baier, F.R. Wurm, V. Mailänder, K. Landfester, K. Steinbrink
IL-2 functionalized nanocapsules for T cell-based immunotherapy
Targeting of T cells for biomedical applications still remains an obstacle as they disclose reduced endocytic activities. Here, by coupling the cytokine interleukin-2 (IL-2) to the surface of hydroxyethyl starch nanocapsules, scientists of the MPI-P and the University Medical Center Mainz demonstrated a direct and specific T cell targeting in vitro and in vivo by IL-2 receptor mediated internalization.
© MPI-P (2017)
By coupling the cytokine interleukin-2 to the surface of hydroxyethylstarch nanocapsules, a direct and specific T cell targeting in vitro and in vivo by receptor mediated internalization can be achieved.
 
loading content
Go to Editor View