Dr. David Ng
David pursued his chemistry studies at the National University of Singapore and received his B.Sc. degree with first class honours in 2009. In 2010, he accepted a scholarship offered by the Max Planck Institute for Polymer Research and moved with Prof. Dr. Tanja Weil to Ulm to work on developing dendritic biohybrids as precise nanotransporters for biomedical applications, focusing on organic chemistry and macromolecular design. David received his doctorate with summa cum laude in 2014 and thereafter worked as a group leader in the Institute of Organic Chemistry III at Ulm University until 2016. Since 2016, he leads the adaptive polymeric materials group at the Max Planck Institute for Polymer Research to develop synthetic macromolecular strategies into smart nanotherapeutics.
Research Interests - Adaptive Polymeric Materials
Complex macromolecular functions are often dictated by their precision in molecular make-up and their positioning within a three dimensional space to create individual domains with highly specialized functions. Our strategy combines the absolute atomic precision of biomolecules together with synthetic and polymer chemistry to create a new generation of adaptive hybrid materials spanning multiple length scales. This "adaptation" is generally instill upon by synthetic functional moieties i.e. boronic acids where our group has a strong focus on to impact physiological features i.e. pH changes, reactive oxygen species.
We are equipped with the chemical expertise on different macromolecular platforms ranging from synthetic (dendrimers/polymers) to biological origin (peptides, proteins, DNA). With a core focus on precision at the atomic and/or nanoscale, we develop synthetic tools at the interface of chemistry and biology to construct an optimal nanodevice for a target biomedical application (i.e. cancer therapeutics, antiviral, antimicrobial, regenerative medicine).
Y. Tokura, S. Harvey, C. Chen, Y. Wu, D.Y.W. Ng, T. Weil. Fabrication of defined polydopamine nanostructures by DNA origami-templated polymerization. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201711560.
D.Y.W. Ng, R. Vill, Y. Wu, K. Koynov, Y. Tokura, W. Liu, S. Sihler, A. Kreyes, S. Ritz, H. Barth, U. Ziener, T. Weil. Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues. Nat. Commun. 2017, 8 (1850), 1.
C. Seidler, D.Y.W. Ng, T. Weil. Native protein hydrogels by dynamic boronic acid chemistry. Tetrahedron Special Issue to Ben Feringa 2017, 73, 4979.
S. Schmid, D.Y.W. Ng, E. Mena-Osteritz, Y. Wu, T. Weil, P. Bäuerle. Self-assembling Oligothiophene-Bolaamphiphiles for Loading and Controlled Release of Doxorubicin. Chem. Commun. 2016, 15, 3235.
C. Seidler, D.Y.W. Ng, Y. Wu, T. Weil. pH Responsive Supramolecular Core-Shell Protein Hybrids. Supramol. Chem. 2016, 28, 742.
T. Wang, N. Zabarska, K. Monczak, M. Lamla, D.Y.W. Ng, S. Rau, T. Weil. Receptor Selective Ruthenium-Somatostatin Photosensitizer for Cancer Targeted Photodynamic Applications. Chem. Commun. 2015, 51, 12552.
Y. Wu, D.Y.W. Ng, S.L. Kuan, T. Weil. Protein-Polymer Therapeutics– A Macromolecular Perspective. Biomaterials Sci. 2015, 3, 21.
D.Y.W. Ng, Y. Wu, S.L. Kuan, T. Weil*. Programming Supramolecular Biohybrids as Precision Therapeutics. Acc. Chem. Res. 2014, 47, 12, 3471.
D.Y.W. Ng, M. Arzt, Y. Wu, Seah Ling Kuan, M. Lamla, T. Weil. Constructing hybrid protein zymogens through protective dendritic assembly. Angew. Chem. Int. Ed. 2014, 53, 324.