Principal Investigator

Dr Johannes Hunger
Dr Johannes Hunger
Group Leader
Phone:+49 6131 379-765Fax:+49 6131 379-360

Latest Publications

Our paper showing that CF3-groups critically enhance the binding of thiourea catalysts to ketones – a NMR and FT-IR study has been accepted for publication in J. Mol. Liq.

October 2019

Our paper showing that CF3-groups critically enhance the binding of thiourea catalysts to ketones – a NMR and FT-IR study has been accepted for publication in J. Mol. Liq. [more]
Our paper showing that the Hydrophobic pattern of alkylated ureas markedly affects water rotation and hydrogen bond dynamics in aqueous solution has been accepted for publication in PhysChemChemPhys.

September 2019

Our paper showing that the Hydrophobic pattern of alkylated ureas markedly affects water rotation and hydrogen bond dynamics in aqueous solution has been accepted for publication in PhysChemChemPhys. [more]
Our paper showing that the Hydrogen bond structure and dynamics of TADDOL asymmetricorgano-catalysts correlate with catalytic activity has been accepted for publication in Chemistry - A European Journal.

May 2019

Our paper showing that the Hydrogen bond structure and dynamics of TADDOL asymmetric
organo-catalysts correlate with catalytic activity
has been accepted for publication in Chemistry - A European Journal. [more]
Our paper on Dynamics of Dicyanamide in Ionic Liquids Are Dominated by Local Interactions has been accepted for publication in J. Phys. Chem B.

February 2019

Our paper on Dynamics of Dicyanamide in Ionic Liquids Are Dominated by Local Interactions has been accepted for publication in J. Phys. Chem B. [more]
Our paper on Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation has been accepted for publication in Angewandte Chemie.

November 2018

Our paper on Specific Ion Effects on an Oligopeptide: Bidentate binding matters for the Guanidinium Cation has been accepted for publication in Angewandte Chemie. [more]
Our collaborative paper on the Large Hydrogen-Bond Mismatch between TMAO and Urea Promotes Their Hydrophobic Association has been published in Chem.

October 2018

Our collaborative paper on the Large Hydrogen-Bond Mismatch between TMAO and Urea Promotes Their Hydrophobic Association has been published in Chem. [more]
Christian Malm, Heejae Kim, Manfred Wagner, and Johannes Hunger have a paper on Complexity in acid-base titrations: Multimer formation between phosphoric acids and imines accepted to Chem. Eur. J.

June 2017

Christian Malm, Heejae Kim, Manfred Wagner, and Johannes Hunger have a paper on Complexity in acid-base titrations: Multimer formation between phosphoric acids and imines accepted to Chem. Eur. J. [more]

Liquid Dynamics Group - ERC FASTO-CAT

ERC Fundamentals of AsymmeTric Organo CATalysis (FASTO-CAT)

Asymmetric organo-catalysis represents a metal-free alternative to conventional asymmetric transition metal catalysis. These organo-catalysts emerged only in the recent decades and can provide high stereoselectivity. Therefore, they are particularly suited for the synthesis of biologically relevant molecules, where chirality is important for various functions, e.g. for the pharmaceutical activity of drugs. Despite the success of these organo-chemical routes, remarkably little is known about the reactive intermediates in a realistic environment. Since these intermediates, however, induce chirality in the first place, we experimentally quantify such reactive intermediates, and analyse their nature and geometry.

We study reactive intermediates using a combination of different spectroscopic methods: With ultrafast two-color and two-dimensional infrared spectroscopy we detect molecular vibrations, in order to trace changes in the molecules’ environment in real-time. By means of dielectric and NMR spectroscopy he investigate the electronic structure and binding motifs between the catalyst and the substrate. This combination of techniques thus allows probing molecular interactions on all timescales relevant to catalytic processes ranging from femtoseconds to seconds. Correlating the thus obtained information with the enantiomeric excess obtained in catalytic processes allows identifying the key elements that are required for stereocontrol. Such molecular-level insights will provide fundamental parameters for the optimization of reaction conditions and routes towards novel catalytic routes.

The goal of optimizing catalysis as well as predicting new catalytic routes opens different fields of application for the asymmetric organo-catalysis. For example in medicine, one example may be a more efficient and targeted production of antimalarial medication.

 
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