Publications

2019

Jana De Vrieze, Benoit Louage, Kim Deswarte, Zifu Zhong, Ruben De Coen, Simon Van Herck, Lutz Nuhn, Camilla Kaas Frich, Alexander N. Zelikin, Stefan Lienenklaus, Niek N. Sanders, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest – “Potent lymphatic translocation and spatial control over innate immune activation by polymer-lipid amphiphile conjugates of small molecule TLR7/8 agonists”, Angewandte Chemie International Edition 2019accepted, DOI: 10.1002/anie.20190568.

Ruben De Coen, Lutz Nuhn, Bruno G. De Geest – “Engineering mannosylated nanogels with membrane-disruptive properties“, Polymer Chemistry 201910, 4297-4304.

Nadine Leber, Leonard Kaps, Aiting Yang, Misbah Aslam, Mariacristina Giardino, Sebastian Rosigkeit, Asmaa Mostafa, Lutz Nuhn,1Detlef Schuppan,1Rudolf Zentel1– “α-Mannosyl-Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages”, Macromolecular Bioscience 201919, 1900162.

Zhiyue Zhang, Hui Li, Sabah Kasmi, Simon Van Herck, Kim Deswarte, Bart N. Lambrecht, Richard Hoogenboom, Lutz Nuhn, Bruno G. De Geest – “A Synthetic Transiently Thermoresponsive Homopolymer with UCST Behavior within a Physiologically Relevant Window”, Angewandte Chemie International Edition 201958, 7866-7872; Angewandte Chemie 2019131, 7948-7954.

2018

Alexandra Van Driessche, Agnese Kocere, Hannelien Everaert, Lutz Nuhn, Simon Van Herck, Gareth Griffiths, Federico Felaroli, Bruno G. De Geest – “pH-Sensitive Hydrazone Linked Doxorubicin-Nanogels via Polymeric-Activated Ester Scaffolds: Synthesis, Assembly, and In Vitro and In Vivo Evaluation in Tumor-Bearing Zebrafish”, Chemistry of Materials 201830, 8587−8596.

Simon Van Herck, Kim Deswarte, Lutz Nuhn, Zifu Zhong, Joao Portela Catani, Yupeng Li, Niek N. Sanders, Stefan Lienenklaus, Stefaan De Koker, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest – “Lymph node targeted immune-activation by small molecule TLR7/8 agonists conjugated to highly stable acid-degradable block copolymer amphiphiles”, Journal of the American Chemical Society 2018140, 14300-14307.

Lien Lybaert, Karim Vermaelen, Bruno G. De Geest,1Lutz Nuhn1– “Immunoengineering through Cancer Vaccines – a Personalized and Multi-step Vaccine Approach towards Precise Cancer Immunity”, Journal of Controlled Release 2018289, 125-145.

Lutz Nuhn,1Stefaan De Koker,1Sandra Van Lint,1Zifu Zhong, João Portela Catani, Francis Combes, Kim Deswarte, Yupeng Li, Bart N. Lambrecht, Stefan Lienenklaus, Niek N. Sanders, Sunil A. David, Jan Tavernier, Bruno G. De Geest – “Nanoparticle-conjugated TLR7/8 Agonist Localized Immunotherapy Provokes Safe and Synergistic Antitumoral Responses”, Advanced Materials 201830, 1803397.

Matthias Bros, Lutz Nuhn, Johanna Simon, Lorna Moll, Volker Mailänder, Katharina Landfester, Stephan Grabbe – “The Protein Corona as a Confounding Variable of Nanoparticle-mediated Targeted Vaccine Delivery”, Frontiers in Immunology 20189, 1760.

Lutz Nuhn,1Simon Van Herck,1Andreas Best, Kim Deswarte, Maria Kokkinopoulou, Ingo Lieberwirth, Kaloian Koynov, Bart N. Lambrecht, Bruno G. De Geest – “FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles”, Angewandte Chemie International Edition 201857, 10760-10764; Angewandte Chemie 2018130, 10920-10925.

Lutz Nuhn,1Evangelia Bolli,1Sam Massa, Isabel Vandenberghe, Kiavash Movahedi, Bart Devreese, Jo A. Van Ginderarchter, Bruno G. De Geest – “Targeting Protumoral Tumor-associated Macrophages with Nanobody-functionalized Nanogels through SPAAC Ligation”, Bioconjugate Chemistry 201829, 2394-2405.

Lutz Nuhn, Lien Van Hoecke, Kim Deswarte, Bert Schepen, Yupeng Li, Bart N. Lambrecht, Stefaan De Koker, Sunil A. David, Xavier Saelens, Bruno G. De Geest – “Potent Anti-Viral Vaccine Adjuvant Based on pH-Degradable Nanogels with Covalently Linked Small Molecule Imidazoquinoline TLR7/8 Agonist”, Biomaterials 2018178, 643-651.

Simon Van Herck, Lien Van Hoecke, Benoit Louage, Lien Lybaert, Ruben De Coen, Sabah Kasmi, Aaron P. Esser-Kahn, Sunil A. David, Lutz Nuhn, Bert Schepens, Xavier Saelens, Bruno G. De Geest “Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant”, Bioconjugate Chemistry 201829, 748-760.

2017

Sabah Kasmi, Benoit Louage, Lutz Nuhn, Glenn Verstraete, Simon Van Herck, Mies van Steenbergen, Chris Vervaet, Wim E. Hennink, Bruno G. De Geest – “Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization”, Polymer Chemistry 20178, 6544-6557.

Nadine Leber, Lutz Nuhn, Rudolf Zentel – “Cationic Nanohydrogel Particles For Therapeutic Oligonucleotide Delivery”, Macromolecular Bioscience 2017,17, 1700092.

Wouter Grymonpré, Nils Bostijn, Simon Van Herck, Glenn Verstraete, Valérie Vanhoorne, Lutz Nuhn, Pieter Rombouts, Thomas De Beer, Jean Paul Remon, Chris Vervaet – “Downstream processing from hot-melt extrusion towards tablets: a quality by design approach”,International Journal of Pharmaceutics 2017531, 235-245.

Glenn Verstraete, Lotte Vandenbussche, Sabah Kasmi, Lutz Nuhn, Davinia Brouckaert, Jeroen Van Renterghem, Wouter Grymonpré, Valérie Vanhoorne, Tom Coenye, Bruno G. De Geest, Thomas De Beer, Jean Paul Remon, Chris Vervaet – “Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis”, International Journal of Pharmaceutics 2017,529, 218-226.

Lien Lybaert, Nari Ryu, Lutz Nuhn, Riet De Rycke, Olivier De Wever, Alfred Chon, Aaron Esser-Kahn, Bruno G. De Geest – “Cancer Cell Lysate entrapment in CaCO3Engineered with Polymeric TRL-agonists – Immunomodulating Microparticles in View of Personalized Anti-Tumor Vaccination”,Chemistry of Materials 2017,29, 4209-4217.

Benoit Louage, Mies J. van Steenbergen, Lutz Nuhn, Martijn D. P. Risseeuw, Izet Karalic, Johan Winne, Serge Van Calenbergh, Wim E. Hennink, Bruno G. De Geest – “Micellar Paclitaxel-Initiated RAFT Polymer Conjugates with Acid-Sensitive Behavior”, ACS Macro Letters 2017,6, 272-276.

Nane Vanparijs, Lutz Nuhn, Bruno G. De Geest – “Transiently Thermoresponsive Polymers and Their Application in Biomedicine“, Chemical Society Reviews 2017,46, 1193-1239. 

Nadine Leber, Leonard Kaps, Misbah Aslam, Jonathan Schupp, Alexander Brose, David Schäffel, Karl Fischer, Mustafa Diken, Dennis Strand, Kaloian Koynov, Andrea Tuettenberg, Lutz Nuhn,1Rudolf Zentel,1Detlef Schuppan1– “SiRNA-Mediated In Vivo Gene Knockdown by Acid-Degradable Cationic Nanohydrogel Particles“, Journal of Controlled Release 2017248, 10-23.

2016

Zhiyue Zhang, Nane Vanparijs, Stef Vanhaaren, Filip E. Du Prez, Lutz Nuhn,1Bruno G. De Geest1– “Squaric Ester Amides as Hydrolysis-Resistant Functional Groups for Protein-Conjugation of RAFT Polymers“, Polymer Chemistry 20167, 7242-7248.

Nane Vanparijs,1Lutz Nuhn,1Samantha J. Paluck, Maria Kokkinopoulou, Ingo Lieberwirth, Heather D. Maynard, Bruno G. De Geest – “Core/Shell Protein-Reactive Nanogels via a Combination of RAFT Polymerization and Vinyl Sulfone Postmodification“, Nanomedicine (Lond.) 201611, 2631-2662.

Jörg Reichenwallner, Anja Thomas, Lutz Nuhn, Tobias Johann, Annette Meister, Holger Frey, Dariush Hinderberger – “Tunable Dynamic Hydrophobic Attachment of Guest Molecules in Amphiphilic Core-Shell Polymers“, Polymer Chemistry 20167, 5783-5798.

Benoit Louage, Lutz Nuhn, Martijn D. P. Risseeuw, Nane Vanparijs, Ruben De Coen, Izet Karalic, Serge Van Calenbergh, Bruno G. De Geest – “Well-Defined Polymer-Paclitaxel Prodrugs by a Grafting-from-Drug Approach”, Angewandte Chemie International Edition 201655, 11791-11796; Angewandte Chemie 2016128, 11967-11973.

Lutz Nuhn, Nane Vanparijs, Ans De Beuckelaer, Lien Lybaert, Glenn Verstraete, Kim Deswarte, Stephan Lienenklaus, Nikunj M. Shukla, Alex C. D. Salyer, Bart N. Lambrecht, Johan Grooten, Sunil A. David, Stefaan De Koker, Bruno G. De Geest – “pH-Degradable Imidazoquinoline-Ligated Nanogels for Lymph Node Focused Immune Activation”, Proceedings of the National Academy of Sciences 2016,113, 8098-8103.

Ruben De Coen, Nane Vanparijs, Martijn D. P. Risseeuw, Lien Lybaert, Benoit Louage, Stefaan De Koker, Vimal Kumar, Johan Grooten, Leeanne Taylor, Neil Ayres, Serge Van Calenbergh, Lutz Nuhn,1Bruno G. De Geest1– “pH-Degradable Mannosylated Nanogels for Dendritic Cell Targeting”, Biomacromolecules 2016,17, 2479-2488.

Lutz Nuhn, Leonard Kaps, Mustafa Diken, Detlef Schuppan, Rudolf Zentel – “Reductive Decationizable Block Copolymers for Stimuli-Responsive mRNA Delivery”, Macromolecular Rapid Communications 201637, 924-933.

Lien Lybaert, Nane Vanparijs, Kaat Fierens, Martijn Schuijs, Lutz Nuhn, Bart N. Lambrecht, Bruno G. De Geest – “A Generic Polymer-Protein Ligation Strategy for Vaccine Delivery”, Biomacromolecules 201617, 874-881.

Zhyiue Zhang, Bert Schepens, Lutz Nuhn, Xavier Saelens, Michael Schotsaert, Nico Callewaert, Riet De Rycke, Qilu Zhang, Sébastien Moins, Samira Benali, Laetitia Mespouille, Richard Hoogenboom, Bruno G. De Geest– “Influenza-Binding Sialylated Polymer Coated Gold Nanoparticles Prepared via RAFT Polymerization and Reductive Amination“, Chemical Communications 201652, 3352-3355.

Sabah Kasmi, Benoit Louage, Lutz Nuhn, Alexandra Van Driessche, Jan Van Deun, Izet Karalic, Martijn Risseeuw, Serge Van Calenbergh, Richard Hoogenboom, Riet De Rycke, Oliver De Wever, Wim E. Hennink, Bruno G. De Geest – “Transiently Responsive Block Copolymer Micelles Based on N-(2-Hydroxypropyl)methacrylamide Engineered with Hydrolyzable Ethylcarbonate Side Chains”, Biomacromolecules 201617, 119-127.

2015

Leonard Kaps,1Lutz Nuhn,1Mishah Aslam, Alexander Brose, Friedrich Foerster, Sebastian Rosigkeit, Patricia Renz, Rosario Heck, Yong Ook Kim, Ingo Lieberwirth, Detlef Schuppan, Rudolf Zentel – “In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles”, Advanced Healthcare Materials 20154, 2809-2815

Elise Lepeltier,1Lutz Nuhn,1Claus-Michael Lehr, Rudolf Zentel – “Not Just for Tumor Targeting: Unmet Medical Needs and Opportunities for Nanomedicines”,Nanomedicine (Lond.) 201510, 3147-3166.

Lutz Nuhn – “Enhancing Gene Knockdown Efficiencies by Comparing siRNA-Loaded Cationic Nanogel Particles of Different Sizes”, RNA&Disease 20152, e469.

Bettina Krieg, Markus Hirsch, Erik Scholz, Lutz Nuhn, Ilja Tabujew, Heiko Bauer, Sandra Decker, Andriy Khobta, Manfred Schmidt,Wolfgang Tremel, Rudolf Zentel, Kalina Peneva, Kaloian Koynov, A. James Mason, Mark Helm – „New Techniques to assess in vitro release of siRNA from nanoscale polyplexes”, Pharmaceutical Research 201532, 1957-1974.

Sebastian Hartmann,1Lutz Nuhn,1Björn Palitzsch, Markus Glaffig, Natascha Stergiou, Bastian Gerlitzki, Edgar Schmitt, Rudolf Zentel, Horst Kunz – “CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines”, Advanced Healthcare Materials 20154, 522-527.

2014

Lutz Nuhn, Lydia Braun, Iris Overhoff, Annette Kelsch, David Schaeffel, Kaloian Koynov, Rudolf Zentel – “Degradable Cationic Nanohydrogel Particles for Stimuli-Responsive Release of siRNA”,Macromolecular Rapid Communications 201435, 2057-2064.

Lutz Nuhn, Stephanie Tomcin, Kanjiro Miyata, Volker Mailänder, Katharina Landfester, Kazunori Kataoka, Rudolf Zentel – “Size-Dependent Knockdown Potential of siRNA-Loaded Cationic Nanohydrogel Particles”, Biomacromolecules 201415, 4111-4121.

Lutz Nuhn – “Addressing Dendritic Cells for Anticancer Immunity”, Journal of Antibody Drug Conjugates 2014, DOI:10.14229/jadc.2014.8.15.002 

Lutz Nuhn, Sabine Gietzen, Kristin Mohr, Karl Fischer, Kazuko Toh, Kanjiro Miyata, Yu Matsumoto, Kazunori Kataoka, Manfred Schmidt, Rudolf Zentel – “Aggregation Behavior of Cationic Nanohydrogel Particles in Human Blood Serum”, Biomacromolecules 201415, 1526-1533.

Lutz Nuhn, Matthias Barz, Rudolf Zentel – “New Perspectives of HPMA-based Co-polymers Derived by Post-Polymerization Modification”, Macromolecular Bioscience 201414, 607-618

Markus Glaffig, Bjö̧rn Palitzsch, Sebastian Hartmann, Christoph Schüll, Lutz Nuhn, Bastian Gerlitzki, Edgar Schmitt, Holger Frey, Horst Kunz – “A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen Presentation on a Hyperbranched Polymer”, Chemistry – A European Journal 201420, 4232-4236.

Lutz Nuhn, Iris Overhoff, Marcel Sperner, Katrin Kaltenberg,Rudolf Zentel– “RAFT-Polymerized Poly(hexafluoroisopropyl methacrylate)s as Precursor for Functional Water-Soluble Polymers”, Polymer Chemistry 2014, 5, 2484-2495.

2013

Christian Moers, Lutz Nuhn, Marcel Wissel, Rene Stangenberg, Mihail Mondeshki, Elena Berger-Nicoletti, Anja Thomas, David Schaeffel, Kaloian Koynov, Markus Klapper, Rudolf Zentel, Holger Frey – “Supramolecular Linear-g-hyperbranched Graft Polymers: Topology and Binding Strength of Hyperbranched Side-Chains”, Macromolecules 201346, 9544-5953.

Lutz Nuhn,1Sebastian Hartmann,1Björn Palitzsch, Bastian Gerlitzki, Edgar Schmitt, Rudolf Zentel, Horst Kunz – “Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines”, Angewandte Chemie International Edition 201352, 10652-10656; Angewandte Chemie 2013125, 10846-10850.

Lutz Nuhn, Christoph Schüll, Holger Frey, Rudolf Zentel – “Combining Ring-Opening Multibranching and RAFT Polymerization: Multifunctional Linear-Hyperbranched Block Copolymers via Hyperbranched Macro Chain Transfer Agents”, Macromolecules 201346, 2892-2904.

2012

Christoph Schüll, Lutz Nuhn, Christine Mangold, Eva Christ, Rudolf Zentel, Holger Frey – “Linear-Hyperbranched Graft-Copolymers via Grafting-to Strategy based on Hyperbranched Dendron Analogues and Reactive Ester Polymers”, Macromolecules 201245, 5901-5910.

Lutz Nuhn, Markus Hirsch, Bettina Krieg, Kaloian Koynov, Karl Fischer, Manfred Schmidt, Mark Helm, Rudolf Zentel – Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular Delivery”, ACS Nano 20126, 2198-2214. 

2011

Daniel J Siegwart, Kathryn A Whitehead, Lutz Nuhn, Gaurav Sahay, Hao Cheng, Shan Jiang, Minglin Ma, Abigail Lytton-Jean, Arturo Vegas, Patrick Fenton, Christopher G Levins, Kevin T Love, Haeshin Lee, Christina Cortez, Sean P Collins, Ying Fei Li, Janice Jang, William Querbes, Christopher Zurenko, Tatiana Novobrantseva, Robert Langer, Daniel G Anderson – “Combinatorial Synthesis of Chemically Diverse Core-Shell Nanoparticles for Intracellular Delivery”, Proceedings of the National Academy of Sciences 2011108, 12996-13001.

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1Both authors contributed equally.

 
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