Dr. David Ng
David pursued his chemistry studies at the National University of Singapore and received his B.Sc. degree with first class honours in 2009. In 2010, he accepted a scholarship offered by the Max Planck Institute for Polymer Research (MPIP) and moved to Ulm under the supervision of Prof. Tanja Weil. David graduated with summa cum laude in 2014 and worked as a junior group leader in the Institute of Organic Chemistry III at Ulm University. He subsequently moved to the MPIP and leads the life-like nanosystems group focusing on precision (bio)macromolecules and stimulus responsive chemistry. In 2019, he is featured as one of the emerging “key figures that will shape the future of research at the interface of chemistry and biology” in the ChemBioTalents issue (Wiley VCH).
Chemistry of Self-Assembly in Living Systems
Self-organization in Nature is a fascinating phenomenon where molecules form transient supramolecular or dynamic bonds on demand. In this area, we focus extensively on designing molecules that self-assembles within a living environment i.e. in a cell. This involves the understanding of the biological environment and the necessary triggers in order to control, both time and location, of the assembly process. By creating synthetic architectures within the living cell, we hope to derive nanostructures that would provide complementary functions in biology.
Interface Engineering of (Bio)macromolecule-Polymer Nanostructures
The core focus of this topic uses the architectural perfection of biomacromolecules such as proteins and DNA to provide a framework around polymer chemistry. Nanoscale structures such as DNA origamis and denatured proteins offer a monodisperse template with pre-determined geometry and chemistry. By programming this orientation of functional group exposure on the macromolecular structure, polymerization reactions can be spatially controlled to map a designated architecture.
In addition, these hybrid structures can be made functional and responsive depending on the chemistry that is chosen for both the polymerization and synthetic motifs. We collaborate extensively to bring elucidate the influence of shape in biomedicine and physiological environments.
M. Pieszka, A. M. Sobota, J. Gacanin, T. Weil, D. Y. W. Ng “Orthogonally Stimulated Assembly/Disassembly of Depsi-peptides by Rational Chemical Design” ChemBioChem : a European Journal of Chemical Biology 20, 1376-1381 (2019)
T. Lückerath, T. Strauch, K. Koynov, C. Barner-Kowollik, D. Y. W. Ng, T. Weil "DNA-Polymer Conjugates by Photo-induced RAFT Polymerization" Biomacromolecules 20, 1, 212-221 (2019)
Y. Tokura, S. Harvey, C. Chen, Y. Wu, D.Y.W. Ng, T. Weil. "Fabrication of defined polydopamine nanostructures by DNA origami-templated polymerization" Angew. Chem. Int. Ed. 57, 1587-1591 (2018)
D.Y.W. Ng, R. Vill, Y. Wu, K. Koynov, Y. Tokura, W. Liu, S. Sihler, A. Kreyes, S. Ritz, H. Barth, U. Ziener, T. Weil. "Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues" Nat. Commun. 8 (1850), (2017)
C. Seidler, D.Y.W. Ng, Y. Wu, T. Weil. "pH Responsive Supramolecular Core-Shell Protein Hybrids" Supramol. Chem. 28, 742 (2016)