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<p>Dr. Bikram Keshari Agrawalla</p> Zoom Image

Dr. Bikram Keshari Agrawalla

Recent Publications

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© American Chemical Society (2017)

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© American Chemical Society (2017)

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Dr. Bikram Keshari Agrawalla

C.V.

Bikram Keshari Agrawalla studied Pharmaceutical Sciences at the Biju Patnaik University of Technology, Odisha and received his bachelor’s degree in 2007. For his masters he joined National Institute of Pharmaceutical Education and Research, Kolkata and obtained his MS Pharm degree in 2009. He received his PhD from National University of Singapore in July 2015 under the guidance of Professor Chang Young-Tae. His PhD thesis mainly focuses on the development of Two-Photon fluorescent probes for pancreatic islet cell imaging (for Glucagon secreting alpha cells and Insulin secreting beta cells). He joined Prof. Tanja Weil’s group in Ulm University on September 2015 as a Post-doctoral fellow and worked for the development of Ruthenium based efficient Photosensitizers. In 2016 he moved with the group of Prof. Weil to Max Planck Institute for Polymer Research. His main interest here is to utilize small molecule tools for site specific alteration of proteins to develop novel therapeutics.

Research Topics

    • Organelle directing photodynamic therapy
    • Site specific Protein Functionalization
    • Protein based therapeutics development

    Contact

    Max Planck Institute for Polymer Research
    Ackermannweg 10
    D-55128 Mainz, Germany
    (+49) 6131-379-153 (phone)
    agrawalla@...

    Selected Publications

    B.K. Agrawalla, T. Wang, A. Riegger, M.P. Domogalla, K. Steinbrink, T. Dörfler, X. Chen, F. Boldt, M. Lamla, J. Michaelis, S.L. Kuan, T. Weil. Chemoselective Dual Labelling of Native and Recombinant Proteins. Bioconjugate Chem. 2018, 29, 29–34.

    B.K. Agrawalla, H.W. Lee, W.H. Phue, A.K. Raju, J.J. Kim, H.M. Kim, N.Y. Kang, Y.T. Chang. Two-Photon Dye Cocktail for Dual-Color 3D Imaging of Pancreatic Beta and Alpha Cells in Live Islets. J. Am. Chem. Soc. 2017, 139, 3480–3487.

    S. Chakrabortty, B.K. Agrawalla, A. Stumper, N.M. Vegi, S. Fischer, C. Reichardt, M. Kögler, B. Dietzek, M.F. Buske, C. Buske, S. Rau, T. Weil. Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications. J. Am. Chem. Soc. 2017, 139, 2512–2519.

    B.K. Agrawalla, Y. Chandran, W.H. Phue, S.C. Lee, Y.M. Jeong, S.Y.D. Wan, N.Y. Kang, Y.T. Chang. Glucagon-Secreting Alpha Cell Selective Two-Photon Fluorescent Probe TP-α: For Live Pancreatic Islet Imaging. J. Am. Chem. Soc. 2015, 137, 5355-5362.

    L. Yuan, L. Wang, B.K. Agrawalla, S.J. Park, H. Zhu, B. Sivaraman, J. Peng, Q.H. Xu, Y.T. Chang. Development of Targetable Two-Photon Fluorescent Probes to Image Hypochlorous Acid in Mitochondria and Lysosome in Live Cell and Inflamed Mouse Model. J. Am. Chem. Soc. 2015, 137, 5930-5938.

    P.R. Angelova,¥ B.K. Agrawalla,¥ P.A. Elustondo, J. Gordon, T. Shiba, A.Y. Abramov, Y.T. Chang, E.V. Pavlov. In situ investigation of mammalian inorganic polyphosphate localization using novel selective fluorescent probes JC-D7 and JC-D8. (¥ = Equal contributions) ACS. Chem. Biol. 2014, 9, 2101-2110.

    D. Zhai, B.K. Agrawalla, P.S.F. Eng, S.C.Lee, W. Xu, Y.T. Chang. Development of a fluorescent sensor for an illicit date rape drug–GBL. Chem. Commun. 2013, 49, 6170-6172.

     
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