Cell-based Therapeutics

Development of biocompatible formulations of probiotic cocktails for their specific delivery and release into the gut

Recent findings strongly support a microbial involvement in the development of neurodegenerative diseases like Alzheimer´s disease (AD). In comparison to healthy wild-type mice, Alzheimer´s disease mice showed a remarkable shift in the gut microbiota. Moreover, in a germ-free Alzheimer´s disease mouse model (GF-AD) a drastically reduced Aβ amyloid pathology was determined while the fecal transplantation of GF-AD mice with harvested microbiota from AD mice strongly increased the Aβ pathology.

The aim of the project is the modulation of the gut microbiome to investigate its impact on Aβ pathology. Therefore, new biocompatible formulations of probiotic cocktails for the specific delivery and release into the gut will be developed.

More information about the AD-gut project can be found here

Publications

J. Gačanin, J. Hedrich, S. Sieste, G. Glaßer, I. Lieberwirth, C.V. Synatschke, T. Weil. Autonomous Ultra-Fast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices. Advanced Materials accepted (2018)

J. Gacanin, A. Kovtun, S. Fischer, V. Schwager, J. Quambusch, S. L. Kuan, W. Liu, F. Boldt, C. Li, Z. Yang, D. Liu, Y. Wu, T. Weil, H. Barth, and A. Ignatius. "Spatiotemporally Controlled Release of Rho-Inhibiting C3 Toxin from a Protein–DNA Hybrid Hydrogel for Targeted Inhibition of Osteoclast Formation and Activity" Adv. Healthcare Mater. 6, 1700392 (2017)

The article is a collaboration with researchers at the Institute of Orthopedic Research and Biomechanics, Trauma Research Center, University of Ulm (Germany) and the Institute of Pharmacology and Toxicology, University of Ulm (Germany)

The authors are grateful to the financial support by the Horizon 2020 project “AD GUT” (No. 686271), and by the German Research Foundation (DFG) in the framework of the Collaborative Research Center CRC1149 (INST 40/491-1, INST 40/482-1) as well as the National Natural Science Foundation of China (No. 21534007).

C. Seidler, D. Y.W. Ng, T. Weil. "Native protein hydrogels by dynamic boronic acid chemistry" Tetrahedron 73, 4979-4987 (2017)

The authors are grateful to the financial support from the Horizon2020 project “AD GUT” (ID: 686271) as well as the Volkswagenstiftung (Project ID: 86366).

 
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