Dr. Lutz Nuhn
Lutz Nuhn graduated in biomedical chemistry at the Johannes Gutenberg-University Mainz (Germany) in 2010. In 2008/09, he practiced first research experience at MIT with Robert Langer and Daniel G. Anderson. For his PhD, he joined the group of Rudolf Zentel in Mainz (Germany) working on multifunctional carriers for peptide and oligonucleotide delivery by reactive precursor polymers. After a research stay with Prof. Kazunori Kataoka at Tokyo University (Japan), he obtained his doctoral degree in 2014. Afterwards, he became a postdoctoral associate in the group of Bruno G. De Geest at Ghent University (Belgium) working on multifunctional nanogels for lymph node focused immune activation. Since summer 2017, he has joined the group of Tanja Weil at the Max Planck Institute for Polymer Science (Mainz, Germany) as a young group leader.
Lutz Nuhn received scholarships from the German National Academic Foundation (Studienstiftung des deutschen Volkes), the Max Planck Graduate Center (MPGC), the Fonds der Chemischen Industrie (FCI), the Alexander von Humboldt Foundation (AvH) and the Research Foundation Flanders (FWO). He is currently a Liebig fellow of the FCI and a project leader in the DFG Collaborative Research Center SFB-1066 “Nanodimensional Polymer Therapeutics for Tumor Therapy” (Project B4: “Polymer induced tumor-immunotherapy by in situ activation of antigen presenting cells”).
At the interface between materials chemistry and life science we want to design novel polymeric drug delivery systems and study their potency to improve pathologic phenomena in living cells and tissues. Thereby, our primary research interests focus on the design of nano-sized vaccines and anti-cancer immunotherapeutics. For this purpose, we develop well-defined block copolymers with self-assembling and responsive properties. The resulting nano-sized carriers can sense various stimuli including temperature, pH or light and provide reactivity to amino acid residues as well as specific receptor binding properties. Key feature of them is their biodegradability towards nanoparticle disassembly under physiologically relevant conditions over time.
Towards the development of vaccines against insidious intracellular pathogens and cancer, we utilize these nanocarriers for engineering selective immune-responses in vitro and in vivo. Moreover, novel strategies to modulate immune regulatory properties of the tumor microenvironment are investigated in order to combat cancer via next generation nano-immunotherapeutics.
L. Nuhn, M. Hirsch, B. Krieg, K. Koynov, K. Fischer, M. Schmidt, M. Helm, R. Zentel “Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular Delivery”, ACS Nano 2012, 6, 2198-2214.
L. Nuhn, S. Hartmann, B. Palitzsch, B. Gerlitzki, E. Schmitt, R. Zentel, H. Kunz “Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines”, Angewandte Chemie International Edition 2013, 52, 10652-10656; Angewandte Chemie 2013, 125, 10846-10850.
L. Kaps, L. Nuhn, M. Aslam, A. Brose, F. Foerster, S. Rosigkeit, P. Renz, R. Heck, Y. Ook Kim, I. Lieberwirth, D. Schuppan, R. Zentel “In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles”, Advanced Healthcare Materials 2015, 4, 2809-2815.
S. Hartmann, L. Nuhn, B. Palitzsch, M. Glaffig, N. Stergiou, B. Gerlitzki, E. Schmitt, R. Zentel, H. Kunz “CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines”, Advanced Healthcare Materials 2015, 4, 522-527.
L. Nuhn, N. Vanparijs, A. De Beuckelaer, L. Lybaert, G. Verstraete, K. Deswarte, S. Lienenklaus, N. M. Shukla, A. C. D. Salyer, B. N. Lambrecht, J. Grooten, S. A. David, S. De Koker, B. G. De Geest “pH-Degradable Imidazoquinoline-Ligated Nanogels for Lymph Node Focused Immune Activation”, Proceedings of the National Academy of Sciences 2016, 113, 8098-8103.