Dr. Lucas Caire da Silva

Lucas Caire da Silva received a bachelor’s degree in chemistry from the University of Campinas (2010, Brazil) before joining the group of Prof. Dr. Kenneth Wagener at the University of Florida in 2011, where he obtained his PhD in polymer chemistry (2015). Lucas’ research work in the Wagener Group involved the synthesis of precision polyolefins, particularly deuterium-labelled branched polyolefins that were used to study the effects of branching on polymer chain dynamics by 2H and 13C solid state NMR methods. After his PhD work, Lucas started his postdoctoral research at the Department of Physical Chemistry of Polymers led by Prof. Dr. Katharina Landfester at the Max Planck Institute for Polymer Research (MPI-P).  His research interests include the development of bio-inspired synthetic vesicular systems, such as bioreactors and artificial organelles, obtained by combining responsive polymer vesicles with chemically active nanomaterials. Since 2020, Lucas has continued to develop his research work on synthetic vesicular systems as a group leader at MPI-P.

Research Interests

We are interested in the engineering of artificial cells inspired by living cells. Our systems feature two essential components: functional semi-permeable synthetic vesicles (lipids, polymers, and hybrids), and active components such as enzymes, proteins, and nanomaterials. Together, they create integrated smart biomimetic systems that can be programmed to perform different tasks. For instance, artificial cells can be used as bioreactors for chemical synthesis, delivery vehicles for biomolecules. Artificial cells can also recreate cellular behavior such as growth, division, and motion, significantly increasing the complexity and applicability of the tasks they can perform. By designing artificial cells from scratch, we are also improving our understanding of how non-living materials once came together to create the first living cells.

For more information, please visit our website.

Selected Publications

S. Cao, T. Ivanov, M. De Souza Melchiors, K. Landfester, L. Caire da Silva
Controlled Membrane Transport in Polymeric Biomimetic Nanoreactors
ChemBioChem: A European Journal of Chemical Biology, 2023, 24, e202200718
A. Jobdeedamrong, S. Cao, I. Harley, D. Crespy, K. Landfester, L. Caire da Silva
Assembly of biomimetic microreactors using caged-coacervate droplets
Nanoscale, 2023, 15, 2561-2566
M. De Souza Melchiors, T. Ivanov, I. Harley, C. Sayer, P. H. H. Araújo, L. Caire da Silva, C. T. J. Ferguson, K. Landfester
Membrane Manipulation of Giant Unilamellar Polymer Vesicles with a Temperature‐Responsive Polymer
Angewandte Chemie International Edition, 2022, 61, e202207998
S. Cao, L. Caire da Silva, K. Landfester
Light-Activated Membrane Transport in Polymeric Cell-Mimics
Angewandte Chemie International Edition, 2022, 61, e202205266
S. Jiang, L. Caire da Silva, T. Ivanov, M. Mottola, K. Landfester
Synthetic Silica Nano‐Organelles for Regulation of Cascade Reactions in Multi‐Compartmentalized Systems
Angewandte Chemie International Edition, 2022, 61, e202113784
Go to Editor View