Max Planck Institute for Polymer Research
Devising biotherapeutics for metastatic cancer and MS-imaging of Tumor Microenvironment
Maria Silva obtained her MSc in Pharmaceutical Sciences in 2016 from the Faculty of Pharmacy, University of Lisbon (FFUL). During her Master degree, she joined Dr. Pedro Gois group to work on Chemical Biology and later, she did a 3-month internship at Sapienza, Università di Roma in Medicinal Chemistry thanks to the Erasmus Programme. In May 2021, she received her PhD degree at FFUL in a joint project under the supervision of Dr. Pedro Gois and Prof. Dr. Gilles Gasser on novel site-selective bioconjugation strategies and their application to targeted photodynamic therapy. In October 2021, she joined the group of Prof. Tanja Weil as a postdoctoral researcher aiming to design new biotherapeutics to address metastatic niches and study the tumor microenvironment by MS-imaging.
1. Maria J. S. A. Silva, Robin Vinck, Youchao Wang, Bruno Saubaméa, Mickaël Tharaud, Johannes Karges, Pedro M. P. Gois and Gilles Gasser: “Towards Selective Delivery of a Ruthenium(II) Polypyridyl Complex-Containing Bombesin Conjugate into Cancer Cells”. ChemBioChem. 2023, 24, e202200647
2. Maria J. S. A. Silva, Rafaela A. N. Cavadas, Hélio Faustino, Luís F. Veiros and Pedro M. P. Gois: “Interactive Bioconjugation at N-terminal Cysteines using O‑Salicylaldehyde Esters towards dual site-selective functionalization. Chem. Eur. J. 2022, 28, e202202377
3. Lujuan Xu, Maria J. S. A. Silva, Pedro M. P. Gois, Seah Ling Kuan and Tanja Weil: “Chemoselective cysteine or disulfide modification via single atom substitution in chloromethyl acryl reagents”. Chem. Sci. 2021, 12, 13321-13330
4. Maria J. S. A. Silva, Hélio Faustino, Jaime A. S. Coelho, Maria V. Pinto, Adelaide Fernandes, Ismael Compañón, Francisco Corzana, Gilles Gasser and Pedro M. P. Gois: "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angew. Chem. Int. Ed. 2021, 60, 10850-10857