Welcome to the department of Prof. Katharina Landfester

Physical Chemistry of Polymers

We design adaptive molecular systems that mimic life and enable next-generation nanomedicine.

Our group explores how molecules give rise to adaptive molecular systems that bridge the gap from fundamental chemistry to life-inspired function. By designing artificial cells and nanocarriers, we investigate how molecules self-assemble, interact at interfaces, and evolve into higher-order systems with emergent, responsive behaviours. Our artificial cells serve as adaptive prototypes of life, dynamically reconfiguring in response to signals, while our nanocarriers provide precision in nanomedicine by tailoring their biological identity through controlled protein interactions. Guided by cutting-edge synthesis, advanced characterization, and interdisciplinary collaboration, we aim to establish the principles by which molecules become active, adaptive systems—creating a foundation for transformative biomedical applications and a deeper understanding of life-like functionality.


Events

Currently no events.


How artificial cells are synthesised
Dr. Lucas Caire da Silva and Prof. Dr. Katharina Landfester, together with other scientists, have managed to recreate an artificial cell in such a way that individual compartments fulfil the functions of a biological cell. more
Nanocapsules for Drug Delivery
The research group led by Prof. Dr. Katharina Landfester lets you take a look behind the scenes. The video explains the individual synthesis steps in the laboratory and which quality controls have to be passed to be able to produce the "perfect" nanocapsule. more

Highlight Publications

Integrating incompatible tandem photobiocatalysis in artificial cells enables metabolic modulation of natural cells
Z. Wang, S. P. Chali, T. P. Doan-Nguyen, S. Kim, V. Mailänder, S. Jiang, K. Landfester
Science Advances, 2025, 11, eadu4828

© 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. more
Engineered protein corona sustains stealth functionality of nanocarriers in plasma
X. Zhang, S. Si, I. Lieberwirth, K. Landfester, V. Mailänder 
Journal of Nanobiotechnology, 2025, 23, 512

© The Authors. Published by Springer Nature 2025 more
Binary peptide coacervates as an active model for biomolecular condensates
S. Cao, P. Zhou, G. Shen, T. Ivanov, X. Yan, K. Landfester, L. Caire da Silva
Nature Communications, 2025, 16, 2407

© The Authors. Published by Springer Nature Limited 2025. more
Nanoparticle characterisation via 2D classification using single particle averaging
I. Harley, A. Kaltbeitzel, F. Mazzotta, K. Koynov, S. S. Lembke, T. P. Doan-Nguyen, K. Landfester, I. Lieberwirth*
Nanoscale Horizons, 2025, 10, 1642

© The Authors. Published by Royal Society of Chemistry 2025 more
Overcoming PEG Antigenicity: Statistical PEG Isomers Reduce Antibody Binding
M. Deuker, D. Schulz, K. Koynov, S. Morsbach, H. Frey, K. Landfester
Advanced Science, 2025, e21061

© 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH more
Temperature Sensing in Agarose/Silk Fibroin Translucent Hydrogels: Preparation of an Environment for Long-Term Observation
M. Micheva, S. Baluschev, K. Landfester
Nanomaterials, 2025, 15, 123

© 2025 by the authors. Licensee MDPI, Basel, Switzerland. more
Co-delivery of STING and TLR7/8 agonists in antigen-based nanocapsules to dendritic cells enhances CD8+T cell-mediated melanoma remission
J. Schunke, N. Hüppe, N. Mangazeev, K.R. Speth, F. Schln, V. Bolduan, P. Schneider, T. Klaus, S. Grabbe, V. Mailänder, M. Fichter
Nano Today 2024, 57, Art. No. 102365

© 2024 Elsevier more
Interfacial Denaturation at the Droplet Simplifies the Formation of Drug-Loaded Protein Nanocapsules to Enhance Immune Response of Cells
S.P. Chali, J.H. Kang, M. Fichter, K.R. Speth, V. Mailänder, K. Landfester
Adv. Sci. 2024, 11, Art. No. 202403668

© 2024 Wiley more
Size-Dependent Photocatalytic Reactivity of Conjugated Microporous Polymer Nanoparticles
Seunghyeon Kim, Xin Zhou, Yungui Li, Qiqi Yang, Xiaomin Liu, Robert Graf, Paul W. M. Blom, Calum T. J. Ferguson,* and Katharina Landfester*

© 2024 The Author(s). Advanced Materials published by Wiley-VCH GmbH more
Controlled Functionalization Strategy of Proteins Preserves their Structural Integrity While Binding to Nanocarriers
A. Mateos-Maroto, M.Y. Gai, M. Brückner, V. Mailänder, S. Morsbach, K. Landfester

Adv. Mater. Interf. 2024, Art. No. 202400472

© 2024 Wiley more
Albumin nanocapsules and nanocrystals for efficient intracellular drug release
S.P. Chali, J. Westmeier, F. Krebs, S. Jiang, F.P. Neesen, D. Uncuer, ;. Schelhaas, D. Grabbe, C. Becker, K. Landfester, K. Steinbrink
Nanoscale Horizons 2024, 9, 1978–1989

© 2024 Royal Society of Chemistry more
Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis 
S. Cao, T. Ivanov, J. Heuer, C. Ferguson, K. Landfester, L. Caire da Silva

Nat. Comm. 2024, 15, 39

© 2024 Nature Communications more

Media

Projekt „Escape“
Frederik Wurm stellt das Projekt „Escape“ vor, in dem es um die Bekämpfung der Weinrebenkrankheit „Esca“ geht. Der Film wurde im Rahmen der 75-Jahr-Feier von Rheinland-Pfalz gedreht. more
Der Kunststoff Bildungspfad
Was weiß ich eigentlich schon alles über Kunststoffe? Vieles kennt man aus dem Schulunterricht, noch mehr aus den Medien, oft mit dem Ergebnis: Es gibt zahlreiche verschiedene Kunststoffe, aber warum und mit welchen Funktionen? Schlecht für die Umwelt ist ein Argument, das uns ständig begegnet. Aber weiß ich auch, wann genau Kunststoffe umweltschädigend sind und wann sie ein echter Wertstoff sind? more
The guest commentary by Prof. Katharina Landfester on "Chemistry of colours" at the Städel Museum in Frankfurt is now online.

Science meets art

The guest commentary by Prof. Katharina Landfester on "Chemistry of colours" at the Städel Museum in Frankfurt is now online.
https://www.youtube.com/watch?v=uJk8BFYtLZk
Talkshow and documentary about plastics
Prof. Katharina Landfester had a TV show appearance at 3Sat Scobel. more

Seminars and lectures

Prof. Katharina Landfester joined Sarah Köster (University of Göttingen) and Joachim Rädler (LMU Munich) to present and discuss the many possibilities of microfluidics in the field of biomimetic material sciences. This online event was part of the discussion series organized by the Max Planck School - Matter to Life. Now available on YouTube.

Microfluidics

Prof. Katharina Landfester joined Sarah Köster (University of Göttingen) and Joachim Rädler (LMU Munich) to present and discuss the many possibilities of microfluidics in the field of biomimetic material sciences. This online event was part of the discussion series organized by the Max Planck School - Matter to Life. Now available on YouTube.
https://www.youtube.com/watch?v=6zVx3rHAFYg
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