Welcome to the department of Prof. Katharina Landfester

Physical Chemistry of Polymers

We design adaptive molecular systems that mimic life and enable next-generation nanomedicine.

Our group explores how molecules give rise to adaptive molecular systems that bridge the gap from fundamental chemistry to life-inspired function. By designing artificial cells and nanocarriers, we investigate how molecules self-assemble, interact at interfaces, and evolve into higher-order systems with emergent, responsive behaviours. Our artificial cells serve as adaptive prototypes of life, dynamically reconfiguring in response to signals, while our nanocarriers provide precision in nanomedicine by tailoring their biological identity through controlled protein interactions. Guided by cutting-edge synthesis, advanced characterization, and interdisciplinary collaboration, we aim to establish the principles by which molecules become active, adaptive systems—creating a foundation for transformative biomedical applications and a deeper understanding of life-like functionality.


March 2026 - Zsigmondy Colloquium

Our team participated in the Zsigmondy Colloquium 2026 in Erlangen under the theme "Characterisation Tools for Particle Systems and Their Functional Assemblies", organized by Prof. Nicolas Vogel (FAU Erlangen). Richard Ziegler delivered a talk on "Design of Peptide Nanocapsules for Biomedical Applications", while Catherina Zambelli presented her research in a poster session. The colloquium continues to support young scientists across academia, research institutions, and industry. more

March 2026 - German Conference on Synthetic Biology

Gabrielle Ong and Florian Deussen represented our group at the German Conference on Synthetic Biology in Münster (March 11–13). Gabrielle presented her poster on “Designing Permeable Artificial Cells for Tumor Microenvironment Modulation”, while Florian delivered a Flash Talk on “Paracrine-like Communication in Polymer-based Artificial Cells via Aptamer Biosensors for Theophylline”. Great science, great presence! more

March 2026 - Defense time!

We are proud to announce that Carina Jung has successfully completed her doctoral dissertation with distinction. Her research, titled "Surface Functionalization of Nanocarriers for Biomedical Applications", represents a significant contribution to the field of nanomedicine and cancer immunotherapy. Carina’s work focuses on the development of advanced protein nanocapsules as next-generation nanovaccines. By precisely tuning the surface chemistry of these nanocarriers — through control of synthesis parameters and innovative functionalization strategies — she has demonstrated a powerful approach to enhance targeted delivery to dendritic cells, the key orchestrators of anti-tumor immune responses. more

March 2026 - Work Package Meeting in Mainz: Advancing Polymer Innovation in Polymers5B

The work package meeting brought together partners from across Europe to review progress in polymer synthesis and characterization, define application-driven material properties, and explore AI-powered optimization tools. Key outcomes included a clear roadmap for scalable production (5–15 kg) and strengthened data exchange between the synthesis teams. The meeting marked a pivotal step toward industrializing sustainable polymer solutions within the EU-funded Polymers5B project. more

March 2026 - Defense time!

Congratulations! Max Schaaf successfully defended his PhD thesis. His research focused on the development of surface-functionalized, drug-loaded liposomes for targeted activation of immune cells. By combining polymer-based design with advanced characterization, he achieved high in vivo targeting specificity (e.g., cDC1 dendritic cells) and stable encapsulation of poorly soluble drugs like diABZI. His work bridges polymer science, nanomedicine, and immunology — paving the way for next-generation precision therapies. more

March 2026 - Defense time!

Congratulations! Daksh successfully defends his PhD at the Max Planck Institute for Polymer Research (MPIP) Thesis: "Automated Correlative Light and Electron Microscopy (CLEM) Using Deep Learning" A groundbreaking approach to fully automated, unsupervised image registration across light and electron microscopy — eliminating manual annotation, enabling high-throughput analysis, and scaling to ultra-high-resolution datasets (up to 11,000×11,000 px). Paving the way for smarter, faster, and more reproducible multimodal biological imaging. more

February 2026 - ICONN 2026

At ICONN 2026 in Sydney, I presented a plenary lecture on Nanocapsules and Coacervates as Artificial Organelles, highlighting our work on artificial cells, small peptide coacervates, and key challenges for nanocapsules in biomedical applications. The conference provided an excellent platform for scientific exchange and discussion. Many thanks to Martina Stenzel and the organising team for an outstanding event, and to colleagues at UNSW Sydney for the opportunity to further exchange and present our work. more

January 2026 - Plenary Lecture at the RSC CNN Interest Group Annual Symposium

In January, our group had the honour of presenting a plenary lecture at the 2026 RSC Chemical Nanoscience & Nanotechnology Interest Group Symposium at Burlington House, London. The historic venue and the inspiring atmosphere in the RSC Library made for a memorable event.
The talk, “Adaptive Nanomedicine: Designing Smart Therapeutic Systems,” led to many engaging questions and lively discussions, highlighting the interdisciplinary interest in nanoscience and its applications in healthcare, catalysis, and materials science.
Thanks to Daniela Carta for the kind invitation and excellent organisation. more

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cDC1 sub-type-specific in vivo targeting of liposomes

M. Schaaf, M. Fichter, L. Jian, F. Schön, C. Jung, P. Schneider, K. Speth, A. Mateos-Maroto, V. Mailänder, K. Koynov, S. Morsbach, K. Landfester
Advanced Science, 2026, e15402

© 2026 The Author(s). Advanced Science published by Wiley-VCH GmbH more

Overcoming PEG Antigenicity: Statistical PEG Isomers Reduce Antibody Binding

M. Deuker, D. Schulz, K. Koynov, S. Morsbach, H. Frey, K. Landfester
Advanced Science, 2026, 13(7), e21061

© 2026 The Author(s). Advanced Science published by Wiley-VCH GmbH more

Integrating incompatible tandem photobiocatalysis in artificial cells enables metabolic modulation of natural cells

Z. Wang, S. P. Chali, T. P. Doan-Nguyen, S. Kim, V. Mailänder, S. Jiang, K. Landfester
Science Advances, 2025, 11, eadu4828

© 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. more

Engineered protein corona sustains stealth functionality of nanocarriers in plasma

X. Zhang, S. Si, I. Lieberwirth, K. Landfester, V. Mailänder 
Journal of Nanobiotechnology, 2025, 23, 512

© The Authors. Published by Springer Nature 2025 more

Binary peptide coacervates as an active model for biomolecular condensates

S. Cao, P. Zhou, G. Shen, T. Ivanov, X. Yan, K. Landfester, L. Caire da Silva
Nature Communications, 2025, 16, 2407

© The Authors. Published by Springer Nature Limited 2025. more

Nanoparticle characterisation via 2D classification using single particle averaging

I. Harley, A. Kaltbeitzel, F. Mazzotta, K. Koynov, S. S. Lembke, T. P. Doan-Nguyen, K. Landfester, I. Lieberwirth*
Nanoscale Horizons, 2025, 10, 1642

© The Authors. Published by Royal Society of Chemistry 2025 more

Temperature Sensing in Agarose/Silk Fibroin Translucent Hydrogels: Preparation of an Environment for Long-Term Observation

M. Micheva, S. Baluschev, K. Landfester
Nanomaterials, 2025, 15, 123

© 2025 by the authors. Licensee MDPI, Basel, Switzerland. more

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