Dr. Yingke Wu

Yingke received his Bachelor degree from Hebei University of Technology (Tianjin, China) in Polymer Materials and Engineering in 2014, and his Master degree from Sichuan University (Sichuan, China) in Polymer Science and Engineering in 2017. In the same year, he joined the group of Tanja Weil at the Max Planck Institute for Polymer Research (MPIP) and completed his PhD in 2021. After a short stint as a postdoctoral researcher, he was promoted to group leader in 2022 for the nanodiamond group at the MPIP.

Research Interest

It is challenging to understand living biological systems due to their high structural complexity and dynamics. Various biological reactions are constantly proceeding, causing an inhomogeneous distribution of different species, temperatures, and forces at the nanoscale. Local and quantitative detection of these environmental parameters and molecules including transient reactive structures with limited lifetimes will advance our understanding of the living systems. However, current methods for measuring certain quantities at the nanoscale are often limited to strict conditions such as low temperature or vacuum and are not suitable for use in living systems. In our group, we are aiming to use recently developed nanodiamond (ND) quantum sensing technology for in-situ probing and manipulating the intracellular parameters such as temperature, pH, and radical species in living systems, and solve current challenges in biology and medicine.

Selected Publications

1.
Wu, Y.; Weil, T.: Recent Developments of Nanodiamond Quantum Sensors for Biological Applications. Advanced Science 9 (19), 2200059 (2022)
2.
Wu, Y.; Alam, M. N. A.; Balasubramanian, P.; Ermakova, A.; Fischer, S.; Barth, H.; Wagner, M.; Raabe, M.; Jelezko, F.; Weil, T. et al.; Weil, T.: Nanodiamond Theranostic for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing. Nano Letters 21 (9), pp. 3780 - 3788 (2021)
3.
Wu, Y.; Cao, S.; Alam, M. N. A.; Raabe, M.; Michel-Souzy, S.; Wang, Z.; Wagner, M.; Ermakova, A.; Cornelissen, J. J. L. M.; Weil, T.: Fluorescent nanodiamonds encapsulated by Cowpea Chlorotic Mottle Virus (CCMV) proteins for intracellular 3D-trajectory analysis. Journal of Materials Chemistry B 9, pp. 5621 - 5627 (2021)
4.
Wu, Y.; Alam, M. N. A.; Balasubramanian, P.; Winterwerber, P.; Ermakova, A.; Müller, M.; Wagner, M.; Jelezko, F.; Raabe, M.; Weil, T.: Fluorescent Nanodiamond-Nanogels for Nanoscale Sensing and Photodynamic Applications. Advanced nanoBiomed research 1 (7), 2000101 (2021)
5.
Harvey, S.; Raabe, M.; Ermakova, A.; Wu, Y.; Zapata, T.; Chen, C.; Lu, H.; Jelezko, F.; Ng, D. Y. W.; Weil, T.: Transferrin‐Coated Nanodiamond–Drug Conjugates for Milliwatt Photothermal Applications. Advanced Therapeutics 2 (11), 1900067 (2019)

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