Dr. Manfred Wagner

Manfred Wagner obtained in 1988 his diploma degree in chemistry from the University of Mainz in the group of Prof. K. Müllen and completed his PhD thesis “Repetitive Diels-Alder reaction to synthesize band structures” in 1993 at the MPI-P under the supervision of K. Müllen. Since 1990 he is responsible for the high resolution NMR department of the Max-Planck-Institute for Polymer Research. His main topics beside the investigation of the microstructure of marco-molecules (e.g. polymers or biomolecules) are all kind of active nuclei like 7Li, 11B, 15N, 19F, 27Al, 29Si and 31P nuclei (and many other nuclei) and their physical and chemical properties/interactions over the last 29 years. He leads the Nanodiamond (ND) group since 2016 to develop new synthetic strategies for nanodiamonds particle with active center in the crystal via HPHT (High Pressure, High Temperature). The synthesis with defect-defined NDs with sizes below 10 nm and controlled positioning of the defect atom(s) has been impossible to date. Their unique features besides the chemical and mechanical stability like photoluminescence, magnetic and electrical properties make it possible to combine attractive qualities such as NIR emission, hyperpolarization and magnetic sensing.

Research Interests

Materials such as polymers or biomolecules are complex chemical, physical, and biological systems that are rarely fully understood in their entirety. For all types of interactions in different length and time scales, a variety of experimental methods are used to generate a greater understanding. One of our main interests is the combination of different methods to understand more about the micro- and macroscopic properties of materials. Which driving force is responsible for the reaction and which three-dimensional structure is necessary to reach the goal? The interaction of physical properties and the chemical functions in structures are very often the key to understanding and for this we combine a variety of methods such as AFM, TEM, FCS, DLS, XPS, MALIDI-TOF, TOF-SIMS and many more. Together with the various experts in our institutes and partners in other faculties, we seek to understand the chemical and physical properties in nano- or micromaterials in any length and time scale to use this knowledge in biological systems.

Selected Publications

Journal Article (137)

Journal Article
Sokkar, P.; Harms, M.; Stürzel, C.; Gilg, A.; Kizilsavas, G.; Raasholm, M.; Preising, N.; Wagner, M.; Kirchhoff, F.; Ständker, L. et al.; Weidinger, G.; Mayer, B.; Münch, J.; Sanchez-Garcia, E.: Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists. Communications Biology 4 (1), 1113 (2021)
Journal Article
Harmsa, M.; Habib, M. M.W.; Nemska, S.; Nicolò, A.; Gilg, A.; Preising, N.; Sokkar, P.; Carmignani, S.; Raasholm, M.; Weidinger, G. et al.; Kizilsavas, G.; Wagner, M.; Ständker, L.; Abadi, A. H.; Jumaa, H.; Kirchhoff, F.; Frossard, N.; Sanchez-Garcia, E.; Münch, J.: An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta Pharmaceutica Sinica B 11 (9), pp. 2694 - 2708 (2021)
Journal Article
Li, M.; Jiang, S.; Haller, A.; Wirsching, S.; Fichter, M.; Simon, J.; Wagner, M.; Mailänder, V.; Gehring, S.; Crespy, D. et al.; Landfester, K.: Encapsulation of polyprodrugs enables an efficient and controlled release of dexamethasone. Nanoscale Horizons (2021)
Journal Article
Nguyen, N. N.; Berger, R.; Wagner, M.; Thiel, J.; Butt, H.-J.; Graf, R.: "Liquid-like" Water in Clathrates Induced by Host-Guest Hydrogen Bonding. The Journal of Physical Chemistry C 125 (28), pp. 15751 - 15757 (2021)
Journal Article
Chen, C.; Singh, M. K.; Wunderlich, K.; Harvey, S.; Whitfield, C.; Zhou, Z.; Wagner, M.; Landfester, K.; Lieberwirth, I.; Fytas, G. et al.; Kremer, K.; Mukherji, D.; Ng, D. Y. W.; Weil, T.: Polymer cyclization for the emergence of hierarchical nanostructures. Nature Communications 12, 3959 (2021)
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