Publikationen | Forschungsgruppe Makromolekulare Therapeutika Dr. Lutz Nuhn

De Vrieze, J.; Baptista, A. P.; Nuhn, L.; Van Herck, S.; Deswarte, K.; Yu, H.; Lambrecht, B. N.; De Geest, B. G.: Lipid Nature and Alkyl Length Influence Lymph Node Accumulation of Lipid-Polyethylene Glycol Amphiphiles. Advanced Therapeutics, 2100079 (2021)

Huppertsberg, A.; Kaps, L.; Zhong, Z.; Schmitt, S.; Stickdorn, J.; Deswarte, K.; Combes, F.; Czysch, C.; De Vrieze, J.; Kasmi, S. et al.; Choteschovsky, N.; Klefenz, A.; Medina-Montano, C.; Winterwerber, P.; Chen, C.; Bros, M.; Lienenklaus, S.; Sanders, N. N.; Koynov, K.; Schuppan, D.; Lambrecht, B. N.; David, S. A.; De Geest, B. G.; Nuhn, L.: Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators. Journal of the American Chemical Society 143 (26), S. 9872 - 9883 (2021)

Bolli, E.; Scherger, M.; Arnouk, S. M.; Antunes, A. R. P.; Straßburger, D.; Urschbach, M.; Stickdorn, J.; De Vlaminck, K.; Movahedi, K.; Räder, H. J. et al.; Hernot, S.; Besenius, P.; Van Ginderachter, J. A.; Nuhn, L.: Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies. Advanced Science, 2004574 (2021)

Scherger, M.; Räder, H. J.; Nuhn, L.: Self‐Immolative RAFT‐Polymer End Group Modification. Macromolecular Rapid Communications, 2000752 (2021)

Jangra, S.; Vrieze, J. D.; Choi, A.; Rathnasinghe, R.; Laghlali, G.; Uvyn, A.; Herck, S. V.; Nuhn, L.; Deswarte, K.; Zhong, Z. et al.; Sanders, N.; Lienenklaus, S.; David, S.; Strohmeier, S.; Amanat, F.; Krammer, F.; Hammad, H.; Lambrecht, B. N.; Coughlan, L.; García-Sastre, A.; de Geest, B.; Schotsaert, M.: Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine. Angewandte Chemie International Edition (2021)

Kappel, C.; Seidl, C.; Medina-Montano, C.; Schinnerer, M.; Alberg, I.; Leps, C.; Sohl, J.; Hartmann, A.-K.; Fichter, M.; Kuske, M. et al.; Schunke, J.; Kuhn, G.; Tubbe, I.; Paßlick, D.; Hobernik, D.; Bent, R.; Haas, K.; Montermann, E.; Walzer, K.; Diken, M.; Schmidt, M.; Zentel, R.; Nuhn, L.; Schild, H.; Tenzer, S.; Mailänder, V.; Barz, M.; Bros, M.; Grabbe, S.: Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells. ACS Nano (2021)

Scherger, M.; Bolli, E.; Antunes, A. R. P.; Arnouk, S.; Stickdorn, J.; Van Driessche, A.; Schild, H.; Grabbe, S.; De Geest, B. G.; Van Ginderachter, J. A. et al.; Nuhn, L.: Transient Multivalent Nanobody Targeting to CD206-Expressing Cells via PH-Degradable Nanogels. Cells 9 (10), 2222 (2020)

Li, H.; Van Herck, S.; Liu, Y.; Hao, Y.; Ding, X.; Nuhn, L.; Zhong, Z.; Combes, F.; Sanders, N. N.; Lienenklaus, S. et al.; Koker, S. D.; David, S. A.; Wang, Y.; De Geest, B. G.; Zhang, Z.: Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy. ACS Biomaterials Science & Engineering 6 (9), S. 4993 - 5000 (2020)

Fuchs, N.; Meta, M.; Schuppan, D. B.; Nuhn, L.; Schirmeister, T.: Novel Opportunities for Cathepsin S Inhibitors in Cancer Immunotherapy by Nanocarrier-Mediated Delivery. Cells 9 (9), 2021 (2020)

Kockelmann, J.; Stickdorn, J.; Kasmi, S.; Vrieze, J. D.; Pieszka, M.; Ng, D. Y. W.; David, S. A.; Geest, B. G. D.; Nuhn, L.: Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels. Biomacromolecules 21 (6), S. 2246 - 2257 (2020)

Vrieze, J. D.; Herck, S. V.; Nuhn, L.; Geest, B. G. D.: Design of pH‐Degradable Polymer‐Lipid Amphiphiles Using a Ketal‐Functionalized RAFT Chain Transfer Agent. Macromolecular Rapid Communications (2020)

Bixenmann, L.; Stickdorn, J.; Nuhn, L.: Amphiphilic poly(esteracetal)s as dual pH- and enzyme-responsive micellar immunodrug delivery systems. Polymer Chemistry 11, S. 2441 - 2456 (2020)

De Coen, R.; Nuhn, L.; Perera, C.; Arista-Romero, M.; Risseeuw, M. D. P.; Freyn, A.; Nachbagauer, R.; Albertazzi, L.; Van Calenbergh, S.; Spiegel, D. A. et al.; Peterson, B. R.; De Geest, B. G.: Synthetic Rhamnose Glycopolymer Cell-Surface Receptor for Endogenous Antibody Recruitment. Biomacromolecules 21, S. 793 - 802 (2020)

Stickdorn, J.; Nuhn, L.: Reactive-ester derived polymer nanogels for cancer immunotherapy. European Polymer Journal 124, 109481 (2020)

Kaps, L.; Leber, N.; Klefenz, A.; Choteschovsky, N.; Zentel, R.; Nuhn, L.; Schuppan, D.: In Vivo siRNA Delivery to Immunosuppressive Liver Macrophages by α-Mannosyl-Functionalized Cationic Nanohydrogel Particles. Cells 9 (8), 1905 (2020)

Lückerath, T.; Koynov, K.; Loescher, S.; Whitfield, C. J.; Nuhn, L.; Walther, A.; Barner-Kowollik, C.; Ng, D. Y. W.; Weil, T.: DNA-Polymer Nanostructures by RAFT Polymerization and Polymerization‐Induced Self-Assembly. Angewandte Chemie International Edition 59 (36), S. 15474 - 15479 (2020)

Lückerath, T.; Koynov, K.; Loescher, S.; Whitfield, C. J.; Nuhn, L.; Walther, A.; Barner-Kowollik, C.; Ng, D. Y. W.; Weil, T.: DNA-Polymer-Nanostrukturen durch RAFT-Polymerisation und polymerisationsinduzierte Selbstassemblierung. Angewandte Chemie 132 (36), S. 15602 - 15607 (2020)

De Vrieze, J.; Louage, B.; Deswarte, K.; Zhong, Z.; De Coen, R.; Van Herck, S.; Nuhn, L.; Kaas Frich, C.; Zelikin, A. N.; Lienenklaus, S. et al.; Sanders, N. N.; Lambrecht, B. N.; David, S. A.; De Geest, B. G.: Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists. Angewandte Chemie International Edition 58 (43), S. 15390 - 15395 (2019)

De Vrieze, J.; Louage, B.; Deswarte, K.; Zhong, Z.; De Coen, R.; Van Herck, S.; Nuhn, L.; Kaas Frich, C.; Zelikin, A. N.; Lienenklaus, S. et al.; Sanders, N. N.; Lambrecht, B. N.; David, S. A.; De Geest, B. G.: Amphiphile Polymer‐Lipidkonjugate zur potenten lymphatischen Anreicherung von TLR7/8‐Agonisten ermöglichen eine örtlich begrenzte Aktivierung des angeborenen Immunsystems. Angewandte Chemie 131 (43), S. 15535 - 15541 (2019)

Zhang, Z.; Li, H.; Kasmi, S.; Van Herck, S.; Deswarte, K.; Lambrecht, B. N.; Hoogenboom, R.; Nuhn, L.; De Geest, B. G.: A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window. Angewandte Chemie International Edition 58 (23), S. 7866 - 7872 (2019)