Dr. Lutz Nuhn

Lutz Nuhn graduated in biomedical chemistry at the Johannes Gutenberg-University Mainz (Germany) in 2010. In 2008/09, he practiced first research experience at MIT with Robert Langer and Daniel G. Anderson. For his PhD, he joined the group of Rudolf Zentel in Mainz (Germany) working on multifunctional carriers for peptide and oligonucleotide delivery by reactive precursor polymers. After a research stay with Prof. Kazunori Kataoka at Tokyo University (Japan), he obtained his doctoral degree in 2014. Afterwards, he became a postdoctoral associate in the group of Bruno G. De Geest at Ghent University (Belgium) working on multifunctional nanogels for lymph node focused immune activation. Since summer 2017, he has joined the group of Tanja Weil at the Max Planck Institute for Polymer Science (Mainz, Germany) as a young group leader.

Lutz Nuhn received scholarships from the German National Academic Foundation (Studienstiftung des deutschen Volkes), the Max Planck Graduate Center (MPGC), the Fonds der Chemischen Industrie (FCI), the Alexander von Humboldt Foundation (AvH) and the Research Foundation Flanders (FWO). Since his return to Mainz he has become a Liebig fellow of the FCI and a project leader in the DFG Collaborative Research Center SFB-1066 “Nanodimensional Polymer Therapeutics for Tumor Therapy” (Project B3: "Treating primary and secondary liver tumors by adressing tolerance inducing M2-macrophages with immunomodulating nanocarriers" and B4: “Polymer induced tumor-immunotherapy by in situ activation of antigen presenting cells”). Since spring 2019, he has been appointed as Emmy-Noether research group leader supported by the German Research Foundation (DFG). 

Research Interests

At the interface between materials chemistry and life science we want to design novel polymeric drug delivery systems and study their potency to improve pathogenic phenomena in living cells and tissues. Thereby, our primary research interests focus on the design of nano-sized vaccines and anti-cancer immunotherapies. For this purpose, we develop well-defined block copolymers with self-assembling and responsive properties. The resulting nano-sized carriers can sense various stimuli including temperature, pH or light and provide reactivity to amino acid residues as well as specific receptor binding properties. Key feature of them is their biodegradability towards nanoparticle disassembly under physiologically relevant conditions over time. Towards the development of vaccines against insidious intracellular pathogens and cancer we utilize these nanocarriers for engineering selective immune-responses in vitro and in vivo. Moreover, novel strategies to modulate the immune regulatory properties of the tumor microenvironment are investigated, too, in order to combat cancer via next generation nano-immunotherapeutics.

Selected Publications

Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Kim Deswarte, Francis Combes, Christian Czysch, Jana De Vrieze, Sabah Kasmi, Niklas Choteschovsky, Adrian Klefenz, Carolina Medina-Montano, Pia Winterwerber, Chaojian Chen, Matthias Bros, Stefan Lienenklaus, Niek N. Sanders, Kaloian Koynov, Detlef Schuppan, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest, and Lutz Nuhn, "Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators," Journal of the American Chemical Society 143 (26), 9872-9883 (2021).
Evangelia Bolli, Maximilian Scherger, Sana M. Arnouk, Ana Rita Pombo Antunes, David Straßburger, Moritz Urschbach, Judith Stickdorn, Karen De Vlaminck, Kiavash Movahedi, Hans Joachim Räder, Sophie Hernot, Pol Besenius, Jo A. Van Ginderachter, and Lutz Nuhn, "Targeted Repolarization of Tumor‐Associated Macrophages via Imidazoquinoline‐Linked Nanobodies," Advanced Science , 2004574 (2021).
Lutz Nuhn, Stefaan De Koker, Sandra Van Lint, Zifu Zhong, João Portela Catani, Francis Combes, Kim Deswarte, Yupeng Li, Bart N. Lambrecht, Stefan Lienenklaus, Niek N. Sanders, Sunil A. David, Jan Tavernier, and Bruno G. De Geest, "Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses," Advanced Materials 30 (45), 1803397 (2018).
Lutz Nuhn, S. Van Herck, Andreas Best, K. Deswarte, Maria Kokkinopoulou, Ingo Lieberwirth, Kaloian Koynov, B. N. Lambrecht, and B. G. De Geest, "FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles," Angewandte Chemie International Edition 57 (33), 10760-10764 (2018).
Lutz Nuhn, Nane Vanparijs, Ans De Beuckelaer, Lien Lybaert, Glenn Verstraete, Kim Deswarte, Stefan Lienenklaus, Nikunj M. Shukla, Alex C. D. Salyer, Bart N. Lambrecht, Johan Grooten, Sunil A. David, Stefaan De Koker, and Bruno G. De Geest, "pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation," Proceedings of the National Academy of Sciences of the United States of America 113 (29), 8098-8103 (2016).
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