Publikationen von Lutz Nuhn

De Vrieze, J.; Louage, B.; Deswarte, K.; Zhong, Z.; De Coen, R.; Van Herck, S.; Nuhn, L.; Kaas Frich, C.; Zelikin, A. N.; Lienenklaus, S. et al.; Sanders, N. N.; Lambrecht, B. N.; David, S. A.; De Geest, B. G.: Amphiphile Polymer‐Lipidkonjugate zur potenten lymphatischen Anreicherung von TLR7/8‐Agonisten ermöglichen eine örtlich begrenzte Aktivierung des angeborenen Immunsystems. Angewandte Chemie 131 (43), S. 15535 - 15541 (2019)

Zhang, Z.; Li, H.; Kasmi, S.; Van Herck, S.; Deswarte, K.; Lambrecht, B. N.; Hoogenboom, R.; Nuhn, L.; De Geest, B. G.: A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window. Angewandte Chemie International Edition 58 (23), S. 7866 - 7872 (2019)

Zhang, Z.; Li, H.; Kasmi, S.; Van Herck, S.; Deswarte, K.; Lambrecht, B. N.; Hoogenboom, R.; Nuhn, L.; De Geest, B. G.: Synthetisch hergestellte, transient thermoresponsive Homopolymere mit einer oberen kritischen Lösungstemperatur für physiologisch relevante Anwendungen. Angewandte Chemie 131 (23), S. 7948 - 7954 (2019)

De Coen, R.; Nuhn, L.; De Geest, B. G.: Engineering mannosylated nanogels with membrane-disrupting properties. Polymer Chemistry 10 (31), S. 4297 - 4304 (2019)

Leber, N.; Kaps, L.; Yang, A.; Aslam, M.; Giardino, M.; Klefenz, A.; Choteschovsky, N.; Rosigkeit, S.; Mostafa, A.; Nuhn, L. et al.; Schuppan, D.; Zentel, R.: α-Mannosyl-Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages. Macromolecular Bioscience 19 (7), 1900162 (2019)

Bros, M.; Nuhn, L.; Simon, J.; Moll, L.; Mailänder, V.; Landfester, K.; Grabbe, S.: The Protein Corona as a Confounding variable of nanoparticle-Mediated Targeted vaccine Delivery. Frontiers in immunology 9, 1760 (2018)

Lybaert, L.; Vermaelen, K.; De Geest, B. G.; Nuhn, L.: Immunoengineering through cancer vaccines - A personalized and multi-step vaccine approach towards precise cancer immunity. Journal of Controlled Release 289, S. 125 - 145 (2018)

Nuhn, L.; Bolli, E.; Massa, S.; Vandenberghe, I.; Movahedi, K.; Devreese, B.; Van Ginderachter, J. A.; De Geest, B. G.: Targeting Protumoral Tumor-Associated Macrophages with Nanobody-Functionalized Nanogels through Strain Promoted Azide Alkyne Cycloaddition Ligation. Bioconjugate Chemistry 29 (7), S. 2394 - 2405 (2018)

Nuhn, L.; De Koker, S.; Van Lint, S.; Zhong, Z.; Catani, J. P.; Combes, F.; Deswarte, K.; Li, Y.; Lambrecht, B. N.; Lienenklaus, S. et al.; Sanders, N. N.; David, S. A.; Tavernier, J.; De Geest, B. G.: Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses. Advanced Materials 30 (45), 1803397 (2018)

Nuhn, L.; Van Herck, S.; Best, A.; Deswarte, K.; Kokkinopoulou, M.; Lieberwirth, I.; Koynov, K.; Lambrecht, B. N.; De Geest, B. G.: FRET Monitoring of Intracellular Ketal Hydrolysis in Synthetic Nanoparticles. Angewandte Chemie International Edition 57 (33), S. 10760 - 10764 (2018)

Nuhn, L.; Van Hoecke, L.; Deswarte, K.; Schepens, B.; Li, Y. P.; Lambrecht, B. N.; De Koker, S.; David, S. A.; Saelens, X.; De Geest, B. G.: Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist. Biomaterials 178, S. 643 - 651 (2018)

Van Driessche, A.; Kocere, A.; Everaert, H.; Nuhn, L.; Van Herck, S.; Griffiths, G.; Fenaroli, F.; De Geest, B. G.: pH-Sensitive Hydrazone-Linked Doxorubicin Nanogels via Polymeric-Activated Ester Scaffolds: Synthesis, Assembly, and In Vitro and In Vivo Evaluation in Tumor-Bearing Zebrafish. Chemistry of Materials 30 (23), S. 8587 - 8596 (2018)

Van Herck, S.; Deswartep, K.; Nuhn, L.; Zhong, Z.; Catani, J. P. P.; Li, Y.; Sanders, N. N.; Lienenklaus, S.; De Koker, S.; Lambrecht, B. N. et al.; David, S. A.; De Geest, B. G.: Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles-TLR7/8 Agonist Conjugates. Journal of the American Chemical Society 140 (43), S. 14300 - 14307 (2018)

Van Herck, S.; Van Hoecke, L.; Louage, B.; Lybaert, L.; De Coen, R.; Kasmi, S.; Esser-Kahn, A. P.; David, S. A.; Nuhn, L.; Schepens, B. et al.; Saelens, X.; De Geest, B. G.: Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant. Bioconjugate Chemistry 29 (3), S. 748 - 760 (2018)

Grymonpré, W.; Bostijn, N.; Herck, S.V.; Verstraete, G.; Vanhoorne, V.; Nuhn, L.; Rombouts, P.; Beer, T. D.; Remon, J.P.; Vervaet, C.: Downstream processing from hot-melt extrusion towards tablets: A quality by design approach. International Journal of Pharmaceutics 531 (1), S. 235 - 245 (2017)

Kasmi, S.; Louage, B.; Nuhn, L.; Verstraete, G.; Van Herck, S.; van Steenbergen, M. J.; Vervaet, C.; Hennink, W. E.; De Geest, B. G.: Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization. Polymer Chemistry 8 (42), S. 6544 - 6557 (2017)

Leber, N.; Kaps, L.; Aslam, M.; Schupp, J.; Brose, A.; Schäffel, D.; Fischer, K.; Diken, M.; Strand, D.; Koynov, K. et al.; Tuettenberg, A.; Nuhn, L.; Zentel, R.; Schuppan, D.: SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles. Journal of Controlled Release 248, S. 10 - 23 (2017)

Leber, N.; Nuhn, L.; Zentel, R.: Cationic Nanohydrogel Particles for Therapeutic Oligonucleotide Delivery. Macromolecular Bioscience 17 (10), 1700092 (2017)

Louage, B.; van Steenbergen, M. J.; Nuhn, L.; Risseeuw, M. D. P.; Karalic, I.; Winne, J.; Van Calenbergh, S.; Hennink, W. E.; De Geest, B. G.: Micellar Paclitaxel-Initiated RAFT Polymer Conjugates with Acid-Sensitive Behavior. ACS Macro Letters 6 (3), S. 272 - 276 (2017)

Lybaert, L.; Ryu, K. A.; Nuhn, L.; De Rycke, R.; De Wever, O.; Chon, A. C.; Esser-Kahn, A. P.; De Geest, B. G.: Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Microparticles in View of Personalized Antitumor Vaccination. Chemistry of Materials 29 (10), S. 4209 - 4217 (2017)