Dr. Pierpaolo Moscariello

Pierpaolo Moscariello completed his Master’s degree in Industrial Biotechnologies at the University of Milano-Bicocca (Italy) in 2014. He worked on his master thesis in the laboratory of Rita Levi-Montalcini under the supervision of Dr. Annamaria Colangelo, focusing on mechanisms of neuroprotection mediated by Nerve Growth Factor. He then joined the group of Prof. Heiko Luhmann at the University Medical center in Mainz (Germany) and pursued his PhD under the supervision of Dr. Jana Hedrich on the delivery of therapeutics to the brain by crossing the blood-brain barrier. During his PhD studies, Pierpaolo had the opportunity to improve his knowledge on complex in vitro models and biological environments characterized by intricate cell-cell interactions. He also participated in joined projects with the group of Prof. Tanja Weil aimed at modulating pathophysiology of neurological disorders through the delivery of protein bioconjugates and nanotherapeutics to the brain. In 2018, Pierpaolo joined the group of Prof. Weil at the MPI-P in Mainz as postdoctoral fellow. Here, he started to address new challenges dealing with the complex pathophysiology of tumor microenvironment.

Research interests

As reported by the World Health Organization (http://gco.iarc.fr/), cancer is one of the leading causes of death worldwide. Nowadays, a tumor is no longer considered just a mass of malignant cells proliferating uncontrollably, but rather a complex microenvironment characterized by both the interaction between different cell types (e.g. cancer cells, immune cells, fibroblasts) and the formation of a permissive micro-milieu (pH changes, extracellular matrix remodeling, signaling molecules). In the research group of Microenvironment-driven cell metabolism we work on understanding and modulating tumor microenvironment, metastatic mechanisms and pre-metastatic niche formation. The involvement of cell metabolism in the regulation of these pathophysiological processes has become our primary focus. Indeed, studies over the past decade have shown that metabolism influences or is influenced by virtually every other cellular process, so there is no area in biological research that is free from the impact of cell metabolism. Our goal is to induce perturbations in metabolism-linked processes to address new biomedical challenges in an interdisciplinary effort bridging biology and material science. 

Journal Article (4)

1.
Journal Article
Zhou, Z.; Maxeiner, K.; Moscariello, P.; Xiang, S.; Wu, Y.; Ren, Y.; Whitfield, C.; Xu, L.; Kaltbeitzel, A.; Han, S. et al.; Mücke, D.; Qi, H.; Wagner, M.; Kaiser, U.; Landfester, K.; Lieberwirth, I.; Ng, D. Y. W.; Weil, T.: In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism. Journal of the American Chemical Society 144 (27), pp. 12219 - 12228 (2022)
2.
Journal Article
Zegota, M. M.; Müller, M.; Lantzberg, B.; Kizilsavas, G.; Coelho, J. A. S.; Moscariello, P.; Martínez Negro, M.; Morsbach, S.; Gois, P. M. P.; Wagner, M. et al.; Ng, D. Y. W.; Kuan, S. L.; Weil, T.: Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments. Journal of the American Chemical Society 143 (41), pp. 17047 - 17058 (2021)
3.
Journal Article
Moscariello, P.; Raabe, M.; Liu, W.; Bernhardt, S.; Qi, H.; Kaiser, U.; Wu, Y.; Weil, T.; Luhmann, H. J.; Hedrich, J.: Unraveling In Vivo Brain Transport of Protein‐Coated Fluorescent Nanodiamonds. Small 15 (42), 1902992 (2019)
4.
Journal Article
Moscariello, P.; Ng, D. Y. W.; Jansen, M.; Weil, T.; Luhmann, H. J.; Hedrich, J.: Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates. Advanced Science 5 (5), 1700897 (2018)

Thesis - PhD (1)

5.
Thesis - PhD
Moscariello, P.: In vitro and in vivo investigation of dendronized streptavidin and fluorescent nanodiamonds, two flexible nanosystems efficiently crossing the blood-brain barrier to improve nanotheranostics in neurological disease treatment. Dissertation, Johannes Gutenberg-Universität, Mainz (2018)
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