Publications | Makromolecular Therapeutics Group Prof. Dr. Lutz Nuhn

De Vrieze, J.; Louage, B.; Deswarte, K.; Zhong, Z.; De Coen, R.; Van Herck, S.; Nuhn, L.; Kaas Frich, C.; Zelikin, A. N.; Lienenklaus, S. et al.; Sanders, N. N.; Lambrecht, B. N.; David, S. A.; De Geest, B. G.: Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists. Angewandte Chemie International Edition 58 (43), pp. 15390 - 15395 (2019)

De Vrieze, J.; Louage, B.; Deswarte, K.; Zhong, Z.; De Coen, R.; Van Herck, S.; Nuhn, L.; Kaas Frich, C.; Zelikin, A. N.; Lienenklaus, S. et al.; Sanders, N. N.; Lambrecht, B. N.; David, S. A.; De Geest, B. G.: Amphiphile Polymer‐Lipidkonjugate zur potenten lymphatischen Anreicherung von TLR7/8‐Agonisten ermöglichen eine örtlich begrenzte Aktivierung des angeborenen Immunsystems. Angewandte Chemie 131 (43), pp. 15535 - 15541 (2019)

Zhang, Z.; Li, H.; Kasmi, S.; Van Herck, S.; Deswarte, K.; Lambrecht, B. N.; Hoogenboom, R.; Nuhn, L.; De Geest, B. G.: A Synthetic, Transiently Thermoresponsive Homopolymer with UCST Behaviour within a Physiologically Relevant Window. Angewandte Chemie International Edition 58 (23), pp. 7866 - 7872 (2019)

Zhang, Z.; Li, H.; Kasmi, S.; Van Herck, S.; Deswarte, K.; Lambrecht, B. N.; Hoogenboom, R.; Nuhn, L.; De Geest, B. G.: Synthetisch hergestellte, transient thermoresponsive Homopolymere mit einer oberen kritischen Lösungstemperatur für physiologisch relevante Anwendungen. Angewandte Chemie 131 (23), pp. 7948 - 7954 (2019)

De Coen, R.; Nuhn, L.; De Geest, B. G.: Engineering mannosylated nanogels with membrane-disrupting properties. Polymer Chemistry 10 (31), pp. 4297 - 4304 (2019)

Leber, N.; Kaps, L.; Yang, A.; Aslam, M.; Giardino, M.; Klefenz, A.; Choteschovsky, N.; Rosigkeit, S.; Mostafa, A.; Nuhn, L. et al.; Schuppan, D.; Zentel, R.: α-Mannosyl-Functionalized Cationic Nanohydrogel Particles for Targeted Gene Knockdown in Immunosuppressive Macrophages. Macromolecular Bioscience 19 (7), 1900162 (2019)

Hahlbrock, J.; Arnold-Schild, D.; Stickdorn, J.; Ziss, T.; Bros, M.; Grabbe, S.; Nuhn, L.; Schild, H.: Polymer-mediated tumour immunotherapy by in situ activation of antigen presenting cells. In European Journal of Immunology, 49 (SI) 1 Ed., O116, p. 72 - 72. 2nd Joint Meeting of the German-Society-for-Immunology (DGfl) and the Italian-Society-of-Immunology-Clinical-Immunology-and-Allergology (SIICA), Munich, Germany, September 10, 2019 - September 13, 2019. Wiley-VCH, Weinheim (2019)

Kaps, L.; Nuhn, L.; Choteschovsky, N.; Klefenz, A.; Aslam, M. J.; Zentel, R.; Schuppan, D.: NANOPARTICULAR BISPHOSPHONATE TO SELECTIVELY TARGET AND REPOLARIZE LIVER MACROPHAGES FOR ANTI-FIBROTIC RESPONSES IN experimental LIVER FIBROSIS. In Hepatology, 70 (S1), 1877, p. 1127A - 1127A. Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Boston, MA, November 08, 2019 - November 12, 2019. Wiley (2019)

Kaps, L.; Schuppan, D.; Nuhn, L.; Ashfaq-Khan, M.; Aslam, M.; Klefenz, A.; Choteschovsky, N.: Nanoparticular bisphosphonate to selectively target and repolarize liver macrophages for efficient anti-tumour response. In Journal of Hepatology, 70 (1, Supplement), THU-469, pp. E366 - E367. International Liver Congress, Vienna, AUSTRIA, April 10, 2019 - April 14, 2019. Elsevier, Amsterdam (2019)

Nuhn, L.: Block Copolymer-based Nanogels for Cancer immunotherapy. Emerging Polymer Technologies Summit 2019 (EPTS'19) , Melbourne, Australia (2019)

Nuhn, L.: pH-degradable Nanogels Derived from Reactive Precursor Block Copolymers for Cancer Immunotherapy. 20th Annual Recent Appointees in Polymer Science Meeting (RAPS 2019) , Leeds, UK (2019)

Nuhn, L.: Unfolding Nanogels for Local and Systemic Cancer Immunotherapy. 83rd Prague Meeting on Macromolecules: Polymers in Medicine 2019 , Prague, Czech Republic (2019)

Nuhn, L.: pH-degradable Polymeric Nanogels for Local and Systemic Cancer Immunotherapy. 17th Annual Meeting of the Association for Cancer Immunotherapy CIMT, Mainz, Germany (2019)

Nuhn, L.: Reprogramming the Immune System Towards Cancer Immunity Via Controlled Degradable Nanogels. 22. Steinheimer Gespräche des Fonds der Chemischen Industrie für den Hochschullehrernachwuchs, Mainz, Germany (2019)